Buscemi (Italian pronunciation: [buʃˈʃɛːmi]) is a town and comune of 1,150 inhabitants in the Province of Syracuse, Sicily (Italy).
It is located 52 km west of Syracuse, in the Hyblaean Mountains, precisely on the mountain of Vinnitti (783 m high above sea level); the river Anapo crosses the communal territory. The closest municipalities are Buccheri and Palazzolo Acreide.
The town was founded during the Emirate of Sicily, although the area was settled during the Bronze Age. The ancient Greek colony of Casmene was located in the modern communal territory of Buscemi.
Buscemi was completely destroyed in the 1693 earthquake, and was later rebuilt. Baronial families who held Buscemi include the Ventimiglia and Requisenz, who had a castle whose remains are at the entrance of the town.